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1

Studies on Endophytic Actinomycetes ( I )Streptomycessp. Isolated from Rhododendron and Its Antifungal Activity

Masafumi SHIMIZU, Yoshiko NAKAGAWA, Yukio SATO, Tamotsu FURUMAI, Yasuhiro IGARASHI, Hiroyasu ONAKA, Ryuji YOSHIDA, Hitoshi KUNOH

Journal:

Journal of General Plant Pathology

Year:

2000

Language:

english

File:

PDF, 858 KB

english, 2000

2

Fistupyrone, a Novel Inhibitor of the Infection of Chinese Cabbage by Alternaria brassicicola, from Streptomyces sp. TP-A0569.

IGARASHI, YASUHIRO, OGAWA, MIO, SATO, YUKIO, SAITO, NORIKO, YOSHIDA, RYUJI, KUNOH, HITOSHI, ONAKA, HIROYASU, FURUMAI, TAMOTSU

Journal:

The Journal of Antibiotics

Year:

2000

Language:

english

File:

PDF, 686 KB

english, 2000

3

Disease Resistance of Tissue-cultured Seedlings of Rhododendron after Treatment withStreptomycessp. R-5

Masafumi SHIMIZU, Norikazu FUJITA, Yoshiko NAKAGAWA, Tomio NISHIMURA, Tamotsu FURUMAI, Yasuhiro IGARASHI, Hiroyasu ONAKA, Ryuji YOSHIDA, Hitoshi KUNOH

Journal:

Journal of General Plant Pathology

Year:

2001

Language:

english

File:

PDF, 1.94 MB

english, 2001

4

Goadsporin, a Chemical Substance which Promotes Secondary Metabolism and Morphogenesis in Streptomycetes. I. Purification and Characterization.

ONAKA, HIROYASU, TABATA, HIROKAZU, IGARASHI, YASUHIRO, SATO, YUKIO, FURUMAI, TAMOTSU

Journal:

The Journal of Antibiotics

Year:

2001

Language:

english

File:

PDF, 1.30 MB

english, 2001

5

Site-directed mutagenesis of the A-factor receptor protein:: Val-41 important for DNA-binding and Trp-119 important for ligand-binding

Masakazu Sugiyama, Hiroyasu Onaka, Taishiro Nakagawa, Sueharu Horinouchi

Journal:

Year:

1998

Language:

english

File:

PDF, 493 KB

english, 1998

6

Characterization of the Biosynthetic Gene Cluster of Rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243

ONAKA, Hiroyasu, TANIGUCHI, Shin-ichi, IGARASHI, Yasuhiro, FURUMAI, Tamotsu

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2003

Language:

english

File:

PDF, 641 KB

english, 2003

7

Goadsporin, a Chemical Substance which Promotes Secondary Metabolism and Morphogenesis in Streptomycetes. II. Structure Determination.

IGARASHI, YASUHIRO, KAN, YUKIKO, FUJII, KIYONAGA, FUJITA, TSUYOSHI, HARADA, KEN-ICHI, NAOKI, HIDEO, TABATA, HIROKAZU, ONAKA, HIROYASU, FURUMAI, TAMOTSU

Journal:

The Journal of Antibiotics

Year:

2001

Language:

english

File:

PDF, 500 KB

english, 2001

8

Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

Ozaki, Taro, Yamashita, Kona, Goto, Yuki, Shimomura, Morito, Hayashi, Shohei, Asamizu, Shumpei, Sugai, Yoshinori, Ikeda, Haruo, Suga, Hiroaki, Onaka, Hiroyasu

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 2.48 MB

english, 2017

9

10.1271/kagakutoseibutsu.52.685

ONAKA, Hiroyasu

Year:

2014

File:

PDF, 4.58 MB

2014

10

Coupling Reaction of Indolepyruvic Acid by StaD and Its Product: Implications for Biosynthesis of Indolocarbazole and Violacein

Asamizu, Shumpei, Hirano, Satoshi, Onaka, Hiroyasu, Koshino, Hiroyuki, Shiro, Yoshitsugu, Nagano, Shingo

Journal:

Year:

2012

Language:

english

File:

PDF, 490 KB

english, 2012

11

Association of Induced Disease Resistance of Rhododendron Seedlings with Inoculation of Streptomyces sp. R-5 and Treatment with Actinomycin D and Amphotericin B to the Tissue-culture Medium.

SHIMIZU, MASAFUMI, FURUMAI, TAMOTSU, IGARASHI, YASUHIRO, ONAKA, HIROYASU, NISHIMURA, TOMIO, YOSHIDA, RYUJI, KUNOH, HITOSHI

Journal:

The Journal of Antibiotics

Year:

2001

Language:

english

File:

PDF, 332 KB

english, 2001

12

Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis

Hagihara, Ryota, Katsuyama, Yohei, Sugai, Yoshinori, Onaka, Hiroyasu, Ohnishi, Yasuo

Journal:

The Journal of Antibiotics

Year:

2018

Language:

english

File:

PDF, 706 KB

english, 2018

13

Biosynthesis of Heterocyclic Antibiotics in Actinomycetes and an Approach to Synthesize the Natural Compounds

Onaka, Hiroyasu

Journal:

Actinomycetologica

Year:

2006

Language:

english

File:

PDF, 504 KB

english, 2006

14

Anicemycin, a New Inhibitor of Anchorage-Independent Growth of Tumor Cells from Streptomyces sp. TP-A0648.

Yasuhiro Igarashi, Koushirou Ootsu, Hiroyasu Onaka, Tsuyoshi Fujita, Yoshimasa Uehara, Tamotsu Furumai

Journal:

Year:

2005

File:

PDF, 12 KB

2005

15

ChemInform Abstract: Bioactive Microbial Metabolites. Part 36. Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from Streptomyces sp.

Yasuhiro Igarashi, Youngju Kim, Yasuko In, Toshimasa Ishida, Yukiko Kan, Tsuyoshi Fujita, Takashi Iwashita, Hirokazu Tabata, Hiroyasu Onaka, Tamotsu Furumai

Journal:

Year:

2010

File:

PDF, 18 KB

2010

16

Electron Transfer Activation of Chromopyrrolic Acid by Cytochrome P450 En Route to the Formation of an Antitumor Indolocarbazole Derivative: Theory Supports Experiment

Wang, Yong, Hirao, Hajime, Chen, Hui, Onaka, Hiroyasu, Nagano, Shingo, Shaik, Sason

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 177 KB

english, 2008

17

Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium

Hoshino, Shotaro, Wong, Chin Piow, Ozeki, Masahiro, Zhang, Huiping, Hayashi, Fumiaki, Awakawa, Takayoshi, Asamizu, Shumpei, Onaka, Hiroyasu, Abe, Ikuro

Journal:

The Journal of Antibiotics

Year:

2018

Language:

english

File:

PDF, 688 KB

english, 2018

18

Effective Production of Aromatic Polyketides in Streptomyces using a Combined-Culture Method

Hoshino, Shotaro, Okada, Masahiro, Onaka, Hiroyasu, Abe, Ikuro

Journal:

Natural Product Communications

Year:

2016

Language:

english

File:

PDF, 314 KB

english, 2016

19

ChemInform Abstract: Goadsporin, a Chemical Substance which Promotes Secondary Metabolism and Morphogenesis in Streptomycetes. Part 1. Purification and Characterization.

Hiroyasu Onaka, Hirokazu Tabata, Yasuhiro Igarashi, Yukio Sato, Tamotsu Furumai

Journal:

Year:

2002

File:

PDF, 25 KB

2002

20

Absolute Configuration and Antitumor Activity of Myxochelin A Produced by Nonomuraea pusilla TP-A0861†

Miyanaga, Satoshi, Obata, Takamasa, Onaka, Hiroyasu, Fujita, Tsuyoshi, Saito, Noriko, Sakurai, Hiroaki, Saiki, Ikuo, Furumai, Tamotsu, Igarashi, Yasuhiro

Journal:

The Journal of Antibiotics

Year:

2006

Language:

english

File:

PDF, 488 KB

english, 2006

21

Genome Mining Reveals a Minimum Gene Set for the Biosynthesis of 32-Membered Macrocyclic Thiopeptides Lactazoles

Hayashi, Shohei, Ozaki, Taro, Asamizu, Shumpei, Ikeda, Haruo, Ōmura, Satoshi, Oku, Naoya, Igarashi, Yasuhiro, Tomoda, Hiroshi, Onaka, Hiroyasu

Journal:

Chemistry & Biology

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

22

Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08

Du, Danyao, Katsuyama, Yohei, Onaka, Hiroyasu, Fujie, Manabu, Satoh, Noriyuki, Shin-ya, Kazuo, Ohnishi, Yasuo

Journal:

Year:

2016

Language:

english

File:

PDF, 517 KB

english, 2016

23

A blunt renal trauma case with delayed urinary extravasation

Onaka, Atsuhiko, Ito, Shingo, Oka, Hiroyasu, Ueyama, Toru, Kitaoka, Teruichirou, Matusaka, Masanori, Nakamura, Tatsuya

Year:

2014

File:

PDF, 769 KB

2014

24

Chemical Interactions of Cryptic Actinomycete Metabolite 5‐Alkyl‐1,2,3,4‐tetrahydroquinolines through Aggregate Formation

Sugiyama, Ryosuke, Nakatani, Takahiro, Nishimura, Shinichi, Takenaka, Kei, Ozaki, Taro, Asamizu, Shumpei, Onaka, Hiroyasu, Kakeya, Hideaki

Journal:

Angewandte Chemie

Year:

2019

File:

PDF, 2.17 MB

2019

25

Promiscuous enzymes cooperate at the substrate level en route to lactazole A

Vinogradov, Alexander A., shimomura, morito, Kano, Naokazu, Goto, Yuki, Onaka, Hiroyasu, Suga, Hiroaki

Journal:

Journal of the American Chemical Society

Year:

2020

File:

PDF, 3.84 MB

2020

26

ChemInform Abstract: Fistupyrone, a Novel Inhibitor of the Infection of Chinese Cabbage by Alternaria brassicicola, from Streptomyces sp. TP-A0569

Yasuhiro Igarashi, Mio Ogawa, Yukio Sato, Noriko Saito, Ryuji Yoshida, Hitoshi Kunoh, Hiroyasu Onaka, Tamotsu Furumai

Journal:

Year:

2001

File:

PDF, 27 KB

2001

27

pTONA5: A hyperexpression vector in streptomycetes

Tadashi Hatanaka, Hiroyasu Onaka, Jiro Arima, Misugi Uraji, Yoshiko Uesugi, Hirokazu Usuki, Yukifumi Nishimoto, Masaki Iwabuchi

Journal:

Protein Expression and Purification

Year:

2008

Language:

english

File:

PDF, 387 KB

english, 2008

28

Forthcoming Issues

Hayashi, Shohei, Ozaki, Taro, Asamizu, Shumpei, Ikeda, Haruo, Ōmura, Satoshi, Oku, Naoya, Igarashi, Yasuhiro, Tomoda, Hiroshi, Onaka, Hiroyasu

Journal:

Oral and Maxillofacial Surgery Clinics of North America

Year:

2012

Language:

english

File:

PDF, 33 KB

english, 2012

29

Cytochrome P450 Homolog Is Responsible for C–N Bond Formation between Aglycone and Deoxysugar in the Staurosporine Biosynthesis of Streptomyces sp. TP-A0274

ONAKA, Hiroyasu, ASAMIZU, Shumpei, IGARASHI, Yasuhiro, YOSHIDA, Ryuji, FURUMAI, Tamotsu

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2005

Language:

english

File:

PDF, 176 KB

english, 2005

30

ChemInform Abstract: Chojalactones A-C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium

Hoshino, Shotaro, Wakimoto, Toshiyuki, Onaka, Hiroyasu, Abe, Ikuro

Journal:

Year:

2015

File:

PDF, 20 KB

2015

31

Insights into the Biosynthesis of Dehydroalanines in Goadsporin

Ozaki, Taro, Kurokawa, Yukari, Hayashi, Shohei, Oku, Naoya, Asamizu, Shumpei, Igarashi, Yasuhiro, Onaka, Hiroyasu

Journal:

Year:

2016

Language:

english

File:

PDF, 1.25 MB

english, 2016

32

Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis

Sugiyama, Ryosuke, Nishimura, Shinichi, Ozaki, Taro, Asamizu, Shumpei, Onaka, Hiroyasu, Kakeya, Hideaki

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016

33

Chemical Interactions of Cryptic Actinomycete Metabolite 5‐Alkyl‐1,2,3,4‐tetrahydroquinolines through Aggregate Formation

Sugiyama, Ryosuke, Nakatani, Takahiro, Nishimura, Shinichi, Takenaka, Kei, Ozaki, Taro, Asamizu, Shumpei, Onaka, Hiroyasu, Kakeya, Hideaki

Journal:

Angewandte Chemie

Year:

2019

Language:

english

File:

PDF, 2.17 MB

english, 2019

34

Selective tryptophan determination using tryptophan oxidases involved in bis-indole antibiotic biosynthesis

Kameya, Masafumi, Onaka, Hiroyasu, Asano, Yasuhisa

Journal:

Analytical Biochemistry

Year:

2013

Language:

english

File:

PDF, 933 KB

english, 2013

35

Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis

Hiroyasu Onaka, Taishiro Nakagawa, Sueharu Horinouchi

Journal:

Molecular Microbiology

Year:

1998

Language:

english

File:

PDF, 762 KB

english, 1998

36

Chojalactones A–C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium

Hoshino, Shotaro, Wakimoto, Toshiyuki, Onaka, Hiroyasu, Abe, Ikuro

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 1.15 MB

english, 2015

37

Mycolic acid-containing bacteria activate heterologous secondary metabolite expression in Streptomyces lividans

Onaka, Hiroyasu, Ozaki, Taro, Mori, Yukiko, Izawa, Masumi, Hayashi, Shohei, Asamizu, Shumpei

Journal:

The Journal of Antibiotics

Year:

2015

Language:

english

File:

PDF, 324 KB

english, 2015

38

Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

Hoshino, Shotaro, Ozeki, Masahiro, Awakawa, Takayoshi, Morita, Hiroyuki, Onaka, Hiroyasu, Abe, Ikuro

Journal:

Journal of Natural Products

Year:

2018

Language:

english

File:

PDF, 1.16 MB

english, 2018

39

Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from Streptomyces sp. †

Igarashi, Yasuhiro, Kim, Youngju, In, Yasuko, Ishida, Toshimasa, Kan, Yukiko, Fujita, Tsuyoshi, Iwashita, Takashi, Tabata, Hirokazu, Onaka, Hiroyasu, Furumai, Tamotsu

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 646 KB

english, 2010

40

Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis

Shumpei Asamizu, Yasuo Kato, Yasuhiro Igarashi, Tamotsu Furumai, Hiroyasu Onaka

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 106 KB

english, 2006

41

Genetic approaches to generate hyper-producing strains of goadsporin: the relationships between productivity and gene duplication in secondary metabolite biosynthesis

Haginaka, Kentaro, Asamizu, Shumpei, Ozaki, Taro, Igarashi, Yasuhiro, Furumai, Tamotsu, Onaka, Hiroyasu

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2014

Language:

english

File:

PDF, 482 KB

english, 2014

42

Niizalactams A–C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium

Hoshino, Shotaro, Okada, Masahiro, Wakimoto, Toshiyuki, Zhang, Huiping, Hayashi, Fumiaki, Onaka, Hiroyasu, Abe, Ikuro

Journal:

Journal of Natural Products

Year:

2015

Language:

english

File:

PDF, 930 KB

english, 2015

43

The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor

Yasuo Ohnishi, Shogo Kameyama, Hiroyasu Onaka, Sueharu Horinouchi

Journal:

Molecular Microbiology

Year:

1999

Language:

english

File:

PDF, 473 KB

english, 1999

44

Identification of endophyticStreptomycessp. R-5 and analysis of its antimicrobial metabolites

Masafumi Shimizu, Yasuhiro Igarashi, Tamotsu Furumai, Hiroyasu Onaka, Hitoshi Kunoh

Journal:

Journal of General Plant Pathology

Year:

2004

Language:

english

File:

PDF, 189 KB

english, 2004

45

A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis

Noguchi, Akio, Kitamura, Takeshi, Onaka, Hiroyasu, Horinouchi, Sueharu, Ohnishi, Yasuo

Journal:

Nature Chemical Biology

Year:

2010

Language:

english

File:

PDF, 464 KB

english, 2010

46

10.1271/kagakutoseibutsu.48.660

ONAKA, Hiroyasu, NAGANO, Shingo

Journal:

KAGAKU TO SEIBUTSU

Year:

2010

File:

PDF, 540 KB

2010

47

Biosynthetic Origin of Alchivemycin A, a New Polyketide from Streptomyces and Absolute Configuration of Alchivemycin B

Kim, Youngju, In, Yasuko, Ishida, Toshimasa, Onaka, Hiroyasu, Igarashi, Yasuhiro

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 564 KB

english, 2013

48

Theoretical and Experimental Studies of the Conversion of Chromopyrrolic Acid to an Antitumor Derivative by Cytochrome P450 StaP: The Catalytic Role of Water Molecules

Wang, Yong, Chen, Hui, Makino, Masatomo, Shiro, Yoshitsugu, Nagano, Shingo, Asamizu, Shumpei, Onaka, Hiroyasu, Shaik, Sason

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 4.80 MB

english, 2009

49

Cloning of the Gene Cluster Responsible for Biosynthesis of KS-505a (Longestin), a Unique Tetraterpenoid

HAYASHI, Yutaka, ONAKA, Hiroyasu, ITOH, Nobuya, SETO, Haruo, DAIRI, Tohru

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2007

Language:

english

File:

PDF, 176 KB

english, 2007

50

Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis

Sugiyama, Ryosuke, Nishimura, Shinichi, Ozaki, Taro, Asamizu, Shumpei, Onaka, Hiroyasu, Kakeya, Hideaki

Journal:

Angewandte Chemie

Year:

2016

Language:

english

File:

PDF, 961 KB

english, 2016

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